Diazolidinyl Urea-Cosmetic Grade Preservative（CAS 78491-02-8）
Product Name: Diazolidinyl Urea
Alternative Names: Diazolidinylurea, Diazolidinyl urea, Bis(hydroxymethyl)imidazolidinyl urea, Germall II
CAS No.: 78491-02-8
EINECS No.: 278-928-2
Molecular Formula: C₈H₁₄N₄O₇
Molecular Weight: 278.22 g/mol
Purity: ≥99.0%, Cosmetic Grade
Appearance: White Free-Flowing Powder with Slight Characteristic Odor
Solubility: Freely Soluble in Water (>50% at 25°C), Soluble in Propylene Glycol, Slightly Soluble in Ethanol
Nitrogen Content: 19.0% - 21.5%
pH Value (1% Aqueous Solution): 6.0 - 8.0
Loss on Drying: ≤3.0%
Residue on Ignition: ≤3.0%
Heavy Metals (as Pb): ≤20 ppm
Arsenic (As): ≤2 ppm
Key Characteristics: Broad-spectrum formaldehyde-releasing preservative, excellent efficacy against Gram-negative bacteria (especially Pseudomonas aeruginosa), effective against bacteria, yeast and mold, wide pH compatibility, good water solubility, cost-effective cosmetic preservative system
Storage Condition: Sealed in dry, cool and well-ventilated place, protect from moisture and direct sunlight, keep away from amine-containing substances
Shelf Life: 24 Months under proper storage conditions
MOQ (Minimum Order Quantity): 1KG
Application: Broad-spectrum antimicrobial preservative for cosmetics and personal care products, including creams, lotions, shampoos, conditioners, body washes, wet wipes and other leave-on and rinse-off products
Diazolidinyl Urea, Diazolidinylurea, Cosmetic Grade Preservative, Formaldehyde Releaser, Broad-Spectrum Antimicrobial Preservative, Cosmetic Preservative Raw Material, Imidazolidinyl Urea Derivative
Diazolidinyl Urea-Cosmetic Grade Preservative（CAS 78491-02-8）
Cosmetic Grade Diazolidinyl Urea is a high-purity broad-spectrum formaldehyde-releasing preservative manufactured through controlled condensation of urea and formaldehyde under alkaline conditions, followed by cyclization and purification. As a member of the imidazolidinyl urea family, it acts by slowly hydrolyzing and releasing trace amounts of free formaldehyde in aqueous formulations, which effectively disrupts microbial cellular processes and inhibits the growth of bacteria, yeast and mold.
Diazolidinyl Urea is particularly effective against Gram-negative bacteria, especially Pseudomonas aeruginosa, which is one of the most common and challenging contaminants in cosmetic products. It demonstrates excellent compatibility with most cosmetic ingredients and maintains stable performance across a wide pH range (4.0-9.0). It is frequently combined with parabens, phenoxyethanol, IPBC or other preservatives to form a complete broad-spectrum preservation system. Fully compliant with EU, FDA, China and international cosmetic safety regulations, it is one of the most widely used and cost-effective preservatives in the global cosmetics industry.
Key Benefits
• Broad-Spectrum Antimicrobial Efficacy: Effective against Gram-positive bacteria, Gram-negative bacteria, yeast and mold, providing comprehensive protection for cosmetic products.
• Exceptional Gram-Negative Activity: Especially potent against Pseudomonas aeruginosa and other Gram-negative contaminants, addressing the most common cosmetic preservation challenge.
• Controlled Formaldehyde Release: Slow and steady hydrolysis ensures sustained low-level formaldehyde release, maintaining continuous antimicrobial protection throughout shelf life.
• Wide pH Compatibility: Stable and effective across pH 4.0-9.0, suitable for both acidic and alkaline cosmetic formulations.
• Excellent Water Solubility: Freely soluble in water, easy to incorporate into aqueous cosmetic systems without solubility issues.
• High Formulation Compatibility: Compatible with most cosmetic raw materials including surfactants, emulsifiers, thickeners and active ingredients.
• Cost-Effective Preservation: Delivers reliable broad-spectrum protection at low use levels (0.1-0.5%), offering excellent cost-performance ratio.
• Proven Safety Profile: Approved by CIR, EU SCCS and China NMPA, with decades of safe use history in cosmetics and personal care products.
• Versatile Application: Suitable for both leave-on and rinse-off products, including creams, lotions, shampoos, body washes and wet wipes.
• Synergistic Combination Potential: Works well with parabens, phenoxyethanol, IPBC and other preservatives to create enhanced preservation systems.
Applications
• Skincare Creams & Lotions: Used as primary or co-preservative in facial creams, body lotions, moisturizers and serums for broad-spectrum microbial protection.
• Hair Care Products: Applied in shampoos, conditioners, hair masks and hair treatments to prevent bacterial and fungal contamination during use.
• Body Wash & Cleansing Products: Incorporated into body washes, shower gels, facial cleansers and liquid soaps for rinse-off product preservation.
• Wet Wipes & Towelettes: Ideal preservative for wet wipes, baby wipes (with restrictions) and cosmetic wipes due to excellent water solubility and broad efficacy.
• Sun Care Products: Used in sunscreens, after-sun lotions and tanning products to maintain microbiological safety.
• Hair Color & Perm Products: Preservative system for hair dyes, bleaches, perm solutions and other hair treatment products.
• Baby & Mild Care Products: Can be used in baby care products with concentration restrictions (not for leave-on products under 3 years old per China regulation).
• Makeup & Color Cosmetics: Applied in liquid foundations, mascaras, eyeliners and lip glosses for long-term preservation.
• Custom Preservative Blends: Supports customized development of combined preservative systems with parabens, phenoxyethanol, IPBC and other actives.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | Diazolidinyl Urea | Compliant |
CAS No. | 78491-02-8 | Compliant |
Appearance | White Free-Flowing Powder | Compliant |
Odor | Slight characteristic odor | Compliant |
Purity (Assay) | ≥99.0% | 99.32% |
Nitrogen Content | 19.0% - 21.5% | 20.15% |
pH Value (1% Solution) | 6.0 - 8.0 | 6.85 |
Loss on Drying | ≤3.0% | 1.25% |
Residue on Ignition | ≤3.0% | 0.85% |
Solubility in Water | Clear solution (50% solution) | Clear, fully soluble |
Free Formaldehyde | ≤0.5% | 0.28% |
Heavy Metal (as Pb) | ≤20 ppm | <10 ppm |
Arsenic (As) | ≤2 ppm | <1 ppm |
Lead (Pb) | ≤10 ppm | <2 ppm |
Mercury (Hg) | ≤1 ppm | <0.1 ppm |
Cadmium (Cd) | ≤1 ppm | <0.1 ppm |
Total Aerobic Count | ≤100 CFU/g | <10 CFU/g |
Yeast & Mold | ≤10 CFU/g | <1 CFU/g |
E. coli | Negative | Negative |
Salmonella | Negative | Negative |
Pseudomonas aeruginosa | Negative | Negative |
Staphylococcus aureus | Negative | Negative |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of cosmetic grade Diazolidinyl Urea? A1: The standard MOQ is 1KG, and sample orders are supported for quality inspection and formulation testing.
• Q2: What export certification documents can you provide? A2: We provide complete COA, MSDS, TDS and full set of global customs clearance documents including certificate of origin.
• Q3: Is Diazolidinyl Urea compliant with international cosmetic regulations? A3: It meets EU Annex V, FDA, China Cosmetic Safety Technical Specification and mainstream global cosmetic raw material safety standards, with maximum use level of 0.5% in finished products.
• Q4: What is the recommended usage level in cosmetic formulations? A4: Typical use level is 0.1-0.5% depending on product type; 0.2-0.3% is common for most rinse-off products, 0.3-0.5% for leave-on products requiring stronger protection.
• Q5: Can Diazolidinyl Urea be combined with other preservatives? A5: Yes, it is frequently combined with parabens, phenoxyethanol, IPBC, ethylhexylglycerin and other preservatives to create enhanced broad-spectrum preservation systems.
• Q6: What formulation compatibility considerations should I be aware of? A6: It is compatible with most cosmetic ingredients across pH 4.0-9.0; avoid direct contact with primary/secondary amines (peptides, proteins) as they may react with formaldehyde and reduce preservative efficacy.
• Q7: Do you support long-term stable large-batch supply? A7: Sufficient factory capacity ensures sustainable and stable bulk supply all year round, with consistent quality across batches.
• Q8: What packaging options are available? A8: Standard packaging includes 1KG foil bags, 5KG drums, 25KG fiber drums with inner PE bags; custom packaging is available for bulk orders.
Contact Us
💌 Contact us today for technical data, formulation guidance, and competitive pricing! E-mail:
You Might Also Like
1.ur Products A full range of high-quality cosmetic raw materials, including plant extracts, natural active ingredients, skin care actives and formulation additives. Stable supply & strict quality control.
